How is sickle cell trait different from sickle cell disease? People with sickle
ID: 270121 • Letter: H
Question
How is sickle cell trait different from sickle cell disease?
People with sickle cell disease are homologous for the mutation, whereas those with sickle cell trait are heterozygous for the mutation.
People with sickle cell trait are homologous for the mutation, whereas those with sickle cell disease are heterozygous for the mutation.
Sickle cell disease results from an inherited mutation, and sickle cell trait results from an acquired mutation.
Sickle cell trait results from an inherited mutation, and sickle cell disease results from an acquired mutation.
A.People with sickle cell disease are homologous for the mutation, whereas those with sickle cell trait are heterozygous for the mutation.
B.People with sickle cell trait are homologous for the mutation, whereas those with sickle cell disease are heterozygous for the mutation.
C.Sickle cell disease results from an inherited mutation, and sickle cell trait results from an acquired mutation.
D.Sickle cell trait results from an inherited mutation, and sickle cell disease results from an acquired mutation.
Explanation / Answer
Answer: A) People with sickle cell disease are homologous for the mutation, whereas those with sickle cell trait are heterozygous for the mutation.
When there is sickle trait, the person would be inheriting one of the sickle cell genes and the other gene would be a normal gene. These people would be having some of the normal cells whereas some of the sickle cell genes. These mutations are not acquired and hence last two options are incorrect. Whereas, in sickle cell disease, both the genes would be sickle cell. People with sickle cell trait would not be showing the medical condition. SCD are (SS) and SCT are SA.