I) (because someone asked about it in class) You are following 5 recessive trait
ID: 270170 • Letter: I
Question
I) (because someone asked about it in class) You are following 5 recessive traits in an animal: a b, c, d, and e. Your student gives you a heterozygous animal, and you testcross this animal. You collect the following 10,000 progeny: 2000 acbe 250 cd 10 c 130 wild type 170 be 220 abe 230 a 2120 ac 10 ad 2100 dbe 180 cad 20 cbe 2150 d 230 cdbe 30 adbe 150 cadbe whiuh is iaf relnat whchtts an in ci anad B. What are the map distances between the genes? 2) You are interested in sex determination A. If a patient had a mutation ina gene that was active in late testes differentiation, would the patient show as male or female? What phenotypes would the patient show? EARLY FETAL GONADAL DIFFERENTIATION GADDESG MAP3K1/4 SPI ???? ++ sn--SRY-' SON9--* TESTIS DIFFERENTIATION Testicular ceelomic vessel soxio EGE-A RSP01 ? ?-catenin ? OVARY DIFFERENTIATION B. Two male patients show up in a fertility clinic. Their genomes were examined. One was found to be XX, sry+, while the second patient was found to be XX, sry-. In ONE sentence, explain how the two men could be XX. Would these men be fertile (i.e., able to have children)?Explanation / Answer
2b) The SRY-positive 46,XX males generally have normal male external genitalia, small azoospermic testes, hypergonadotropic hypogonadism, and often present with infertility.
The SRY-negative 46,XX males generally have fully mature male genitalia with descended but small testes , hypospadias and cryptorchidism, complete masculinization and infertility.