For animal cells to use fatty acids as a fuel,_ O coenzyme A acyl transferase I

Question

For animal cells to use fatty acids as a fuel,_ O coenzyme A acyl transferase I must activate the fatty acid to its acyl-CoA derivative O camitine must be transported to the outer membrane of the mitochondria O they must first diffuse into the cell O their CoA derivatives are transported into mitochondria by acyl-CoA transport protein The regulation of B oxidation O is not directly linked to intermediates in fatty acid biosynthesis O does not involve direct regulation of any of the four enzymes of Boxidation O occurs both by transcriptional regulation as well as by regulating transport of O is not glucagon dependent in any cells in humans fatty acids into mitochondria Hormone-directed mobilization of fatty acids stored in adipocytes O uses cGMP as a second messenger O results from the stimulation of hormone-sensitive lipase by insulin o causes phosphorylation of perilipins, resulting in increased access to the O produces glycerol, which is not used by the body as a fuel stored triacylglycerols by lipases

Explanation / Answer

1. Option B is correct.
Fatty acids can not cross the mitochondrial membrane. So, they have to be transported as acyl-CoA derivative by carnitine carrier protein. For this to happen, carnitine has to be transported out of the mitochondria.

2. Option C is correct.
Regulation of beta-oxidation occurs at the transcription level as well as at the transport level.

3. Option C is correct.
Hormone-directed mobilization of fats in adipocytes causes phosphorylation of perilipins. Perilipins are lipoproteins which undergo conformational changes upon phosphorylation thereby exposing stored fats to lipases.

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