QUESTIONS 10-1: Professor Pangloss\' reo 10-1: P has led the box is Chinese Ques
ID: 282832 • Letter: Q
Question
QUESTIONS 10-1: Professor Pangloss' reo 10-1: P has led the box is Chinese Quesdto the loss of labels on 150 tubes of DNA. However, on rganization of a lab freezer written that it contains 50 DNA samples each from a erian and Irish population. Undaunted, and with his se. rmodern genotyping facilities and statistical methods. says that he can assign each of the 150 samples to its ion of origin in a short time, with moderate effort and that On expense. How? uestion 10-2: A population previously unknown to scientists has been contacted in the Amazon region.Would it be ethical to carry out genetic analyses on them? If not, why not? If so, of what kind and in what ways? Question 10-3: It is proposed to sequence the genomes of the entire population of Erewhon and make the sequences publicly available. What benefits and risks would this pose for the Erewhonese and what advice would you offer to the Erewhon Genome Management Committee about how to maximize the benefits and minimize the risks?Explanation / Answer
10-1. Even though the labels were lost, the samples can be categorized by different genotyping techniques like RFLP, RAPD and AFLP. Population genomics study genetic variability at multiple loci including gel electrophoresis and restriction enzyme mapping. Apart from these, a mathematical model known as QTL (Quantitative trait locus) mapping is used for vast data and to help find the genes that are responsible for adaptive phenotypes. Single nucleotide polymorphism (SNPs) is an another handy option for small set of genomic data.
10-2. Genomic information is essentially an information about a particular individual's genetic or epigenetic makeup. It raises problems of informed consent to the use of individual information, privacy and confidentiality, rights to know or not to know, and ownership etc. The proliferate use of genetic testing and screening may improve public health outcomes, but it also implicates significant ethical, legal, and social concerns. Under Health Insurance Portability and Accountability Act (HIPAA), the individual's data should be secured and protected. HIPAA Security Rule more specifically outlines national security standards to protect health data created, received, maintained or transmitted electronically.
10-3. Before sequencing the genomes of the Erewhonese, an assurance must be given to the public that the organic meal is free of artificial chemicals and the committee is completely against genetically modified foods. Only legal data sampling should be done with prior intimation to the individuals (only if they are willing).