Bonnie and David had five children: two boys, both of whom had Menkes disease, a
ID: 29259 • Letter: B
Question
Bonnie and David had five children: two boys, both of whom had Menkes disease, and three girls who were all unaffected. Two of the three girls, Rose and Elizabeth, married. Rose married Sam and they had four children. John, Tony, Ruth and Oliver. John and Tony were affected by Menkes disease but Ruth and Oliver were unaffected. Elizabeth married Mark and they had two boys and two girls, none of whom were affected by Menkes disease. (Note: we have omitted information about the order of birth of brothers and sisters.) a.)Using the information given above, draw a pedigree chart to include all the individuals mentioned. You should show who is affected by Menkes disease and who is not. Label each member of the family whose name is known. b.)Females very rarely manifest Menkes disease in any family. Explain the reason for this. (About four sentences). c.)Choose appropriate letters to represent each of the two alleles, one for Menkes disease and one for normal, and determine the genotype of JohnExplanation / Answer
Consider Bonnie and David have Mm Genes... i. e., heteromorphic. Hence there children will inherit these Genes, In Menkes Disease Females are Carriers and Male are Suferrers as Female have One normal X and males have Abnormal X and Normal Y...