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Many types of cancer can be treated or partially treated with chemotherapy. Canc

ID: 29908 • Letter: M

Question

Many types of cancer can be treated or partially treated with chemotherapy. Cancer cells are known to grow much faster than somatic cells, thus making them vulnerable to drugs that can attack certain phases of cell division. Simply stated, traditional chemotherapy drugs attack cells when they are either in S-phase or in mitosis. This, of course, also harms rapidly growing somatic cells, such as bone marrow, blood cells and hair cells. A group of cancer drugs called anti-metabolites masquerade as nucleotides. How and in which stage of the cell life cycle would these interrupt cell growth? a. Anti-metabolites prevent metabolism in cancer cells, thus this must happen in the Mphase b. Anti-metabolites prevent nucleosomes to coil up into chromosomes, thereby preventing prophase in mitosis to happen c. Anti-metabolites prevent purines and pyrimidines to become the building blocks of DNA, thus this must happen in S-phase where DNA is synthesized d. Anti-metabolites prevent crossing-over in prophase I, thus preventing cancer cells to reproduce sexually e. Anti-metabolites prevent chromosomes to separate in anaphase, leading to an aggregation of genetic cancer DNA and subsequently cyst formation, which must sometimes be removed surgically

Explanation / Answer

. Anti-metabolites prevent purines and pyrimidines to become the building blocks of DNA, thus this must happen in S-phase where DNA is synthesized