In humans, three genomic sites (x, y, and z) are in one haplotype with the order
ID: 30115 • Letter: I
Question
In humans, three genomic sites (x, y, and z) are in one haplotype with the order y-x-z. The x site is not polymorphic until a spontaneous A to G mutation produces two SNVs, x-A and x-G. The y and z sites are polymorphic. The x-G allele arises on a chromosome with a T at site y and a T at site z. Other haplotypes exist at the y and z sites though. For example, there are haplotypes that have an A at site y and a G at site z, and haplotypes that have a G at site y and a C at site z. Suppose at one point, the x-G allele confers a strong selective advantage (individuals carrying it are better able to resist infection with a new flu strain that readily infects individuals carrying the x-A allele). Which of the following do you expect to see after many generations pass? Answer Only the piece of the haplotype carrying the x-G allele will increase in frequency in the human population. There will be various bases at the y and z sites due to mutation and recombination. The piece of the haplotype carrying the y-T and z-T alleles will decrease in frequency in the human population. There will not be any change in the frequency of the x-G, y-T, and z-T haplotype in the human population. The large haplotype carrying the x-G, y-T, and z-T SNP alleles will increase in frequency in the human population.Explanation / Answer
The large haplotype carrying the x-G, y-T, and z-T SNP alleles will increase in frequency in the human population.