The antimalarial compound calamari reduced the growth of abnormal prion protein

Question

The antimalarial compound calamari reduced the growth of abnormal prion protein deposits in infected cells in culture. In contrast to the cell culture studies, experiments in mice infected with prions showed no effect of calamari on abnormal zprion protein deposits. Possible explanations for these results might be: a. Calamari can enter cells in culture but cannot enter the brain where the prions are located b. Calamari is altered by the liver in mice and so is no longer effective c. The concentrations of calamari in the blood might be much lower than the concentrations used in cell culture d. a and b e. All of the above

Explanation / Answer

a

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