Please Help. I need the correct answer in order to pass this quiz. All my other
ID: 303550 • Letter: P
Question
Please Help. I need the correct answer in order to pass this quiz. All my other chegg questions have failed me :(.
Part A
Complete the explanation of how heme regulates the expression of globin genes in cells that synthesize hemoglobin.
Drag the terms on the left to the appropriate blanks on the right to complete the sentences.
ResetHelp dehydrogenase methylase phosphatase kinase oxidation methylation phosphorylation dephosphorylation elF1A elF2B elF3 elF4E The level of free heme controls expression of globin genes through its interaction with heme-controlled At low heme levels, heme dissociates from the heme-controlled thereby causing and inactivation, of elF2. In such a form elF2 forms a stable complex with??? , which makes it unavailable to participate in protein synthesis. When heme levels rise, the is inactivated, and becomes available to participate in translational initiation.Explanation / Answer
The level of free heme controls the expression of globin genes through its interaction with heme-controlled inhibitor kinase. At low heme levels, heme dissociates from the heme-controlled inhibitor kinase, thereby causing phosphorylation, and inactivation of elF2. In such a form elF2 forms a stable complex with elF2B, which makes it unavailable to participate in protein synthesis. When heme levels rise, the heme-controlled inhibitor kinase is inactivated, and elF2 becomes available to participate in translation initiation.