Please explain each questions carefully with details to understand better the co
ID: 30903 • Letter: P
Question
Please explain each questions carefully with details to understand better the concept.
1) Discuss the primary condition that stimulates a beta cell to secrete insulin as well as other possible potentiating factors (including the incretin effect)
2) Describe the primary intracellular condition that results in insulin release when beta cells metabolize glucose, AA, or FAs.
3) Explain the sequence of events involving membrane channels that induces the release of insulin from beta cell secretory vesicles
Explanation / Answer
primary pancreatic beta cells reveal that application of exogenous insulin in the presence or absence of nonstimulatory concentrations of glucose evokes exocytosis mediated by the beta cell insulin receptor.Glucose is the principal regulator of insulin secretion from pancreatic beta cells in islets of Langerhans.glucagon secreted from islet alpha cells potentiates insulin secretion (3), whereas somatostatin secreted from delta cells is a potent inhibitor of glucose-stimulated insulin secretion.
The two incretin hormones gastric inhibitory polypeptide (glucose-dependent insulinotopic polypeptide [GIP]) and glucagon-like peptide 1 (GLP-1) are held responsible for ?50