Place the following events of activation of G-protein coupled receptors in the c
ID: 314663 • Letter: P
Question
Place the following events of activation of G-protein coupled receptors in the correct chronological order. (1=earliest event, 6=latest event)
The G-protein stimulated adenylate cyclase to produce large amounts of cyclic AMP (cAMP) from ATP
Protein kinase A phosphorylates a target protein with the cell
The second messenger cAMP activated protein kinase A
After phosphorylation, the activity of the target protein is altered
A water-soluble hormone binds to a G-protein coupled receptor on the membrane of a target cell
The G protein on the inside of the target cell becomes activated
Explanation / Answer
1). A water-soluble hormone binds to a G-protein coupled receptor on the membrane of a target cell
2). The G protein on the inside of the target cell becomes activated
3). The G-protein stimulated adenylate cyclase to produce large amounts of cyclic AMP (cAMP) from ATP
4). The second messenger cAMP activated protein kinase A
5). Protein kinase A phosphorylates a target protein with the cell
6). After phosphorylation, the activity of the target protein is altered