Part C (2.5 pts) In Heidelberg, Germany, the following allele frequencies are ob

Question

Part C (2.5 pts) In Heidelberg, Germany, the following allele frequencies are observed for the ABO Blood Group: I allelic frequency-0.16 I allelic frequency-0.38 Io allelic frequency- 0.46 What are the expected genotypic frequencies of the following blood types? (This problem involves calculating the genotype frequencies based on the probability of allelic combinations occurring. Make sure you consider all possible ways a particular genotype can derived, particularly for heterozygotes. If you are correct, the sum total of the genotypic frequencies should equal 1.00). SHOW YOUR WORK FOR CREDIT!!!! Type A blood? Type B blood? Type AB blood? Type O blood?

Explanation / Answer

Ans.

Allele frequencies -

IA = 0.16, Ia = 0.38 , Io = 0.46

p + q + r = 1 and

(p + q + r)2 = p2 + 2pq + q2 + 2qr + r2 + 2pr = 1

p2= genotype frequency of IA IA = 0.16*0.16 = 0.0256

q2 = genotype frequency of IaIa = 0.38*0.38 = 0.1444

r2 = genotype frequency of IoIo = 0.46*0.46 = 0.2116

2pq = genotype frequency of IAIa = 2*0.16*0.38 = 0.1216

2qr = genotype frequency of IaIo= 2*0.38*0.46 = 0.3496

2pr = genotype frequency of IAIo = 2*0.16*0.46 = 0.1472

Expected genotype frequencies for -

type A blood - 0.0256 + 0.1472 = 0.1728

type B blood- 0.1444 + 0.3496 = 0.494

type AB blood- 0.1216

type O blood- 0.2116

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