Answer the following questions Put the following processes in the CORRECT order
ID: 3166607 • Letter: A
Question
Answer the following questions
Put the following processes in the CORRECT order for the base excision repair mechanism.(1) DNA glycosylase cuts a base–sugar bond. This results in either an apurinic or apyrimidinic site.
(2) DNA polymerase fills in the missing stretch of DNA using the complementary DNA strand as a template.
(3) Base damage is detected.
(4) AP endonuclease nicks the damaged DNA strand upstream of the damage site.
(5) DNA ligase links the phosphate-sugar backbone of the newly synthesized DNA segment with the remainder of the existing strand.
(6) Deoxyribophosphodiesterase removes a stretch of DNA from the damaged DNA strand. 3, 4, 6, 5, 2, 1 3, 4, 2, 5, 1, 6 3, 1, 4, 6, 2, 5 1, 2, 3, 4, 5, 6 None of the answers is correct.
Explanation / Answer
Answer for question number 1: The correct answwer is B (3, 4, 2, 5, 1, 6).
Answer for question number 2 : The correct answer is B (nucleotide-excision repair/NER).
Explanation : Xeroderma pigmentosum patients are sunlight-sensitive and they develop skin cancers upon exposed to sunlight. NER involved in repair of adducts such as Cyclobutane pyrimidine dimers, 6-4 photoproducts, benzo[a]pyrene-guanine etc.,