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Rem 6 Part A Why is one group given saline belore the morphine? Chapt 5 leaches

ID: 3473437 • Letter: R

Question

Rem 6 Part A Why is one group given saline belore the morphine? Chapt 5 leaches us Bhaf messengers comnunicate to target cels by binding specic eceptor types An agonist is a drug thal can bind an endogenous receptor and mimic the response of the satural messenger In the example below, we will look ialt the eflects of mophine on the perception ofl pain Morphine is a mu opioid agonist and decreases perception or produces analgnia minicking the actions of certain endogenous aplolds A Becaune saline has is own analgeskc efflects hat need to be measured Iit is crisical to always provide a solution, whether saline ow another drug before injecting an analgesk To seeve as a control for the injection of nalosone in the other group of padents eanily depends on the nelative affinvity of the twa drugs Nakawone is My Aaswers mu oplold receptors, and the affinity or nalesone is about ten imes greater than it is for morphine The figue below shows data gathered using human sutjects and a visual analog scale According to the graph. what dise of morphi-decreases pain peeception apprainately 50% ? of ten (thase are mophine at patents recelve 1 mgkg inavenous nalaeane 10 minutes prior to inavenous morphine varying doses As wlth the ferst group the patents neevaluate thelr pain 30 minutes ater morphine + 1 mg/Kg naloxone Part c According totho giap·what dose of moiphme virtualy ..mely decreases ne sensation of pain ? 1 mgkg morphine + saline According to the graph, in the presence of na ne, what dose of morphin. decreases pain perce-about 50%? 10 Dose of morphine (mg/Kg) 5 mokg 9 mokg 10 mgkg

Explanation / Answer

Answers for the following are:

Part-A: Option is B

Part-B: Option is C

Part-C: Option is A

Part-D: Option is B