Part 1: A patient less than 2 years of age with end-stage liver disease was trea
ID: 3514194 • Letter: P
Question
Part 1: A patient less than 2 years of age with end-stage liver disease was treated with liver transplantation. The liver segment allograft came from a living closely-related donor. The patient's and relative's ABO blood type are displayed below. 1. For each person, please fill out what antigens are present on their RBCs and what serum antibodies they should have based on their ABO blood type (Put a plus sign in each box to indicate the presence of each antigen or antibody. Leave the box blank for a negative.) ABO Blood Type RBC antigens Serum Antibodies A B Anti-A Anti-B Relative (donor) B Patient (recipient) ABPart 2: Use of an ABO minor-mismatch allograft was deemed acceptable in light of the patient's poor clinical condition. The patient did well during the postoperative period. 2. Explain why the donor and recipient ABO blood types are compatible for organ donation. Why are they considered a minor mismatch? Does minor mismatch generally pose a problem for blood transfusion or organ transplantation?
Part 3: The patient required several blood transfusions in the postoperative period due to persistently low hemoglobin levels. On post-operative day #2, the patient had 7 g/dL hemoglobin (normal is 9.5 to 13 g/dL for infants) and received 50 mL of type AB packed RBCs, resulting in an adequate response with hemoglobin of 8.4 g/dL. However, that night the patient’s hemoglobin was found to be 6.8 g/dL.
3. What type of illness is the patient suffering from in the post-operative period? What characteristics are associated with this illness
Part 1: A patient less than 2 years of age with end-stage liver disease was treated with liver transplantation. The liver segment allograft came from a living closely-related donor. The patient's and relative's ABO blood type are displayed below. 1. For each person, please fill out what antigens are present on their RBCs and what serum antibodies they should have based on their ABO blood type (Put a plus sign in each box to indicate the presence of each antigen or antibody. Leave the box blank for a negative.) ABO Blood Type RBC antigens Serum Antibodies A B Anti-A Anti-B Relative (donor) B Patient (recipient) AB
Part 2: Use of an ABO minor-mismatch allograft was deemed acceptable in light of the patient's poor clinical condition. The patient did well during the postoperative period. 2. Explain why the donor and recipient ABO blood types are compatible for organ donation. Why are they considered a minor mismatch? Does minor mismatch generally pose a problem for blood transfusion or organ transplantation?
Part 3: The patient required several blood transfusions in the postoperative period due to persistently low hemoglobin levels. On post-operative day #2, the patient had 7 g/dL hemoglobin (normal is 9.5 to 13 g/dL for infants) and received 50 mL of type AB packed RBCs, resulting in an adequate response with hemoglobin of 8.4 g/dL. However, that night the patient’s hemoglobin was found to be 6.8 g/dL.
3. What type of illness is the patient suffering from in the post-operative period? What characteristics are associated with this illness
Part 1: A patient less than 2 years of age with end-stage liver disease was treated with liver transplantation. The liver segment allograft came from a living closely-related donor. The patient's and relative's ABO blood type are displayed below. 1. For each person, please fill out what antigens are present on their RBCs and what serum antibodies they should have based on their ABO blood type (Put a plus sign in each box to indicate the presence of each antigen or antibody. Leave the box blank for a negative.) ABO Blood Type RBC antigens Serum Antibodies A B Anti-A Anti-B Relative (donor) B Patient (recipient) AB
Part 2: Use of an ABO minor-mismatch allograft was deemed acceptable in light of the patient's poor clinical condition. The patient did well during the postoperative period. 2. Explain why the donor and recipient ABO blood types are compatible for organ donation. Why are they considered a minor mismatch? Does minor mismatch generally pose a problem for blood transfusion or organ transplantation?
Part 3: The patient required several blood transfusions in the postoperative period due to persistently low hemoglobin levels. On post-operative day #2, the patient had 7 g/dL hemoglobin (normal is 9.5 to 13 g/dL for infants) and received 50 mL of type AB packed RBCs, resulting in an adequate response with hemoglobin of 8.4 g/dL. However, that night the patient’s hemoglobin was found to be 6.8 g/dL.
3. What type of illness is the patient suffering from in the post-operative period? What characteristics are associated with this illness
Explanation / Answer
1. Patients blood group - AB
Donor blood group - B
2. As the recipient has AB Blood group thus he doesn't have any Antibody against A or B type thus he can safely be infused with any blood group (ABO Type). AB type is called universal recipient (in ABO Typing. I've not included Rh typing as it is not mentioned in question).
3. Postoperative anemia.