Physiology Describe the pathophysiology of the Crohn’s disease in detail. - Afte
ID: 3515176 • Letter: P
Question
Physiology
Describe the pathophysiology of the Crohn’s disease in detail.
- After determining the origin/cause of Crohn’s disease, discuss how the impacted organ and its associated body system is affected. Compare the pathophysiological state caused by Crohn’s disease to the normal physiological state of the affected body system.
- Predict at least one other organ system that is impacted by the pathophysiological state of the primary organ system due Crohn’s disease, and explain how/why this occurs.
- Describe the impact of the pathophysiology on whole body homeostasis.
Explanation / Answer
Ans:Crohn's disease is a chronic inflammatory bowel disease that mostly affects the distal ileum and colon .It may occur in any part of the gastrointestinal tract.Spread of inflammation across the GI tract leads to lymphedema, thickening of the bowel wall and mesentery. Mesenteric lymph nodes enlargement results in hypertrophy of the muscularis mucosae, fibrosis, and stricture formation leading to bowel obstruction.
Signs and symptoms often include abdominal pain, diarrhea, fever, and weight loss.Other complications may occur outside the gastrointestinal tract and include anemia, skin rashes, arthritis, inflammation of the eye, and tiredness.The skin rashes may be due to infections as well as pyoderma gangrenosum or erythema nodosum.Bowel obstruction is commonly associated with patients under diseased conditions who are at greater risk of developing bowel cancer.