Problem 6: Legume RX has spent two years testing the new drug, Sweet-P-2K, to im
ID: 3515504 • Letter: P
Question
Problem 6: Legume RX has spent two years testing the new drug, Sweet-P-2K, to improve renal function in Type II diabetics. Each subject spent year one on placebo and year two on SP-2K. During assessment all subjects were fitted with a transurethral bladder catheter and a venous access port. Each received an IV infusion of Inulin (1 mg/ml) that was adjusted until a steady plasma concentration of 0.01 mg/ml was achieved. Subjects were given an oral glucose load and plasma and urinary inulin and glucose were measured 30 min later. The following results were obtained.
Group
Blood I
mg/ml
Blood G
mg/ml
Urine
ml/min
Urine I
mg/ml
Urine G
mg/ml
Baseline
0.01
1.65
3.0
0.3
5.50
Placebo
0.01
1.66
3.1
0.28
6.42
SP-2K
0.01
1.48
2.2
0.48
4.04
1. What was the baseline GFR in ml/min?
A. 55
B. 60
C. 90
D. 125
E. 140
2. What was the baseline glucose clearance in ml/min?
A. 1
B. 4.95
C. 10
D. 90
E. 125
3. The baseline inulin and glucose clearances are indicative of:
A. Diabetes and normal renal function.
B. Diabetes and impaired renal function
C. Normal Carbohydrate and normal renal function
D. Normal Carbohydrate and impaired renal function
E. Diabetes and renal failure
4. Based on these data, SP-2K:
A. Had little effect on glucose tolerance or renal function.
B. Improved glucose tolerance but not renal function.
C. Had little effect on glucose tolerance but improved renal function.
D. Improved both glucose tolerance and renal function.
E. Made both glucose tolerance and renal function deteriorate faster.
Group
Blood I
mg/ml
Blood G
mg/ml
Urine
ml/min
Urine I
mg/ml
Urine G
mg/ml
Baseline
0.01
1.65
3.0
0.3
5.50
Placebo
0.01
1.66
3.1
0.28
6.42
SP-2K
0.01
1.48
2.2
0.48
4.04
Explanation / Answer
Answer 1. The baseline GFR will be 125 ml/min. GFR is glomerular filtration rate that is amount of fluid filtered in one minute.
Answer 2. Glucose clearance is glucose utilisation in ml per minute. The baseline glucose clearence is 90 ml per minute.
Answer 3. The baseline inulin and glucose clearence are indicative of normal carbohydrates and normal renal function. Inulin is used to test the renal function and filtration.
Answer 4. Based on given data, SP- 2K improved both glucose tolerance and renal function.
Glucose tolerance test is used to measure the glucose utilisation of glucose in plasma glucose. It is very important test used in diabetes. It is gold standard test for diagnosis of type 2 diabetes.