For the next few questions, select from: a) Testosterone b) Estradiol c) Estriol
ID: 3519208 • Letter: F
Question
For the next few questions, select from: a) Testosterone b) Estradiol c) Estriol d) Estrone e) Dihydrotestosterone ab) 5-a-reductase ac) Aromatase 77) A deficiency in the production of this enzyme leads to normal development of the male internal genitalia, but poorly developed external genitalia. 78) A lack of receptors for will result in an individual that develops largely as a female, but will have testes that remain inside the abdomen. 79) This estrogen is produced in women that are not pregnant and have not yet reached menopause. converts androgens into estrogens. 80) 81) This hormone is primarily involved in the development of external genitalia in males. 1 AExplanation / Answer
77)
ab) 5-alpha reductase
The deficiency of the enzyme 5-alpha reductase will result in the production of the hormone called di-hydro testosterone (DHT). DHT has a specific role in the development of male sexual organs before birth. Deficiency of this hormone helps in the development of external genitalia that are appearing as female. They do not look clearly as male. This deficiency also leads to the non-development of facial and body hair.
78)
a) Testosterone
An individual with complete androgen insensitivity will develop as female externally as the development of external genitalia depends on the androgen signaling.
79)
b) Estradiol
It is the strongest and most active form of estrogen. It is made by ovaries, fat cells and adrenals. Every cell in the body has receptors for estradiol. This helps in relieving important menopause complaints.
80)
ac) Aromatase
Aromatase is the enzyme that is expressed in the non-gonadal regions and helps in the peripheral aromatization of androgens into estrone. This comes under extra-glandular synthesis. In fat cells, serum estrogens are increased by the conversion of androgen to estrone. Bone helps in converting testosterone into local estrogen.
81)
a) Testosterone
The abnormal development of external genitalia due to the genetic disorder represented by SRY gene mutations prevents testicular development and eliminates the production of testosterone.