Looking at only the first Germ-line H-chain DNA, for a single mature B cell how

Question

Looking at only the first Germ-line H-chain DNA, for a single mature B cell how many of the above C region gene segments are responsible for producing mIg molecules? How many of the above J molecule region gene segments are responsible for producing mIg? why?

LVH1 LVHn DH1 DH7 DH13 Germ-line H-chain DNA D-J joining LVH1 LVH21 LVHn DH1DH6DHH V-DJ joining Rearranged LVH1 LVH20 L V DJ J,H H-chain 5' DNA Transcription L V DJ Primary RNA transcript Polyadenylation RNA splicing mRNA (A) or Translation Translation L V DJ C Nascent polypeptide or V DJ C or heavy chain heavy chain Figure 5-5 Kuby IMMUNOLOGY, Sixth Edition © 2007 W. H. Freeman and Company

Explanation / Answer

Two C region segments are required(only two region is present in the primary transcript)

Three J region molecule are required (two region is present in the rearranged DNA out of which one region is spliced from the pre mRNA)

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