Anaplerotic reactions are necessary so that they can replace specific intermedia

Question

Anaplerotic reactions are necessary so that they can replace specific intermediates in oxidative pathways. The following reaction is one such reaction. In 1 out of 250,000 people there is a deficiency in the gene that produces the enzyme which catalyzes this reaction and hinders the glucose oxidation and glucose production. Which enzyme in glucose oxidation specifically requires the product of this reaction.

a - aconitase b - enolase c - ?-ketoglutarate dehydrogenase d - phosphohexose isomerase e - citrate synthase

Explanation / Answer

c - ?-ketoglutarate dehydrogenase

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