What is the chemical name and structure of Lipitor? What enzyme does Lipitor inh

Question

What is the chemical name and structure of Lipitor? What enzyme does Lipitor inhibit? What is the reaction catalyzed by the enzyme that Lipitor inhibits (show the reaction including the substrate and product). By what mode of inhibition Lipitor work? (ie competitive, uncompetitive, or mixed inhibition)? Make a sketch of the Lineweaver-Burk plot at differing inhibitor concentrations demonstrate the type of inhibition. How are Vmax and Km affected inhibitor? Use the Michaelis-Menten equation to complete the enzyme kin Km is 1 mM. For an enzyme Michaelis-Menton kinetics, what is the reaction velocity, that displays V (as a percentage of Vmax), observed at: [S] = K_m [S] = 0.5 K_m [S] = 2 K_m [S] = 10 K_m

Explanation / Answer

From V= Vmax*S/(KM+S)

KM= 1mM=10-3M, S= 0.5*10-3M, V= 50*10-9 mole/L.min

50*10-9= Vmax*0.5*10-3/ (1*10-3+0.5*10-3)

50*10-9= Vmax*0.5*10-3/1.5*10-3 ,

Vmax= 50*10-9*3= 150*10-9 moles/L.min

1.V= Vmax[S]/[KM+S]

For S=Km

V= Vmax*KM/(KM+KM)= Vmax/2

2. S =0.5KM

V= Vmax*0.5KM/(KM+0.5KM)= Vmax*0.5/1.5=Vmax/3

3. S=0.1KM

V= Vmax*0.1KM/(KM+0.1KM)= Vmax*0.1/1.1 =Vmax*0.091

4. S=2KM

V= Vmax*2KM/(KM+2KM)= Vmax*2/3 =0.666Vmax

5. S=10Km, V=Vmax* 10KM/11KM= Vmax*10/11=0.91Vmax

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