I need help with the following questions. Thanks! Where are toxins stored if not
ID: 494704 • Letter: I
Question
I need help with the following questions. Thanks!
Where are toxins stored if not excreted? Which organs are particularly susceptible to toxin damage? It is found that a toxin is more toxic when it is given in one large dose then when it isadministered in small doses given at 6-8 hour intervals. It takes a larger total dose toproduce the effect when it is given in small increments than when the toxin is givenas one large dose. Give at least three reasons to explain this phenomenon. Discuss 5 chelating agents and the toxic metals that it can bind. Discuss four major anatomic and physiological properties that are responsible for the "blood brain barrier" in the central nervous system. Complete the following tables: Discuss what an Acetaldehyde Syndrome is. What are the intoxicating effects of alcohol in the body?Explanation / Answer
1) Where are toxins stored if not secreted?
A) The toxins are the absorbed into the blood and they can be spread all over the body through it. If the toxin is present in the body for a very long time, it will be in the fat or bone. The body will not be able to lose the fat if the fat contains toxins which are not detoxified by the liver.
2) Which organs are particularly susceptible to toxin damage?
A) Liver and Kidney are the most susceptible organs to toxin damage.
As the kidney is responsible for the filtration of the blood, the blood carrying the toxicants when passing through the kidney tend to leave certain toxicants upon and hence causing damage to the kidney.
Accumulation of excess fat containing toxins in the liver causes damage.
3) A) Dose is the amount of substance administered at a time, It will determine the degree of effect it produces.
The reasons for not taking the entire dose at once:
4) A) Chelating agents are thorougly capable of binding the toxic metals from the body which in turm can be eliminated from the body thus reducing the toxicity.
Calcium Disodium ethylene diamine Tetraacetic acid
Calcium Disodium DTPA
D-Penicillinamine
2,3-Dimercaprol
Deferoxamine