Assume that cancer results from a point mutation in DNA, which changes the secon
ID: 50859 • Letter: A
Question
Assume that cancer results from a point mutation in DNA, which changes the second nucleotide of the codon CGG. This results in a change of an amino acid (or an amino acid substitution) in a key small protein. In this experiment you will find out what the mutation is and address its consequences.
The following mRNA was translated from a person with cancer. Find the same base mutation in the following sequence from a cancer cell. (Hint: Find the start and stop codons and translate the mRNA into protein). Show your work.
C C C A A A U G G A A C C G G G C A U U C A G G U A A C C U A G C C C
Speculate about the consequences of this point mutation in terms of protein function?
Explanation / Answer
C C C A A A U G G A A C C G G G C A U U C A G G U A A C C U A G C C C
AUG is the start codon codes for methionine . UAG is top codon . the bold region is the sequence of nucleotide codon where the point mutation occured , the G in the codon is replaced by C is replaced ,mutated region in the codon. the mutation in the original codon CGG codes for agrinine mutation caused the change in amino acid CCG which codes for proline which is an essential amino acid .so ther will be a change in structure of amino acid .
consequences of this point mutation in terms of protein function;
point muation involves the change in single base in a nuclotide which changes the production of different protein .it is a exchange at single location in a DNA molecule .sickel cell anemia is a result of point mutation that gene encodes for the heamoglobin results in deformed RBC cell which changes the function of protein