Ignore \"examples in biochemistry \" column. Non-Covalent Interactions Learning
ID: 512300 • Letter: I
Question
Ignore "examples in biochemistry " column. Non-Covalent Interactions Learning Objectives Identify Hydrogen bonds and the functional groups that can form them (1) Compare and contrast the nature of non-covalent interactions (1) Rank them by strength and be able to justify this ranking (1, 2) Explain the similarities between macromolecules with respect to structure formation and structural diversity (3) Predict the effect of changing conditions on macromolecular structure 1. Complete the following table regarding noncovalent interactions. Strength Types of molecules involved in this Example in biochemistry Drawing of the interaction 2. How does the strength of a covalent bond compare to the strength of the non-covalent bonds listed above? What the role of the non-covalent bonds listed above in macromolecular structure formation and stability of the folded macromolecule?
Explanation / Answer
Relative strength of bonds is Ionic Bond> Hydrogen bond> Diploe Bond>Induced dipole interations
Drawing of interaction strength Type of molecules involved in this interaction Example in biochemistry Ionic bond very strong Molecules with full permanent opposite charges Sodium chloride Hydrogen bond strong compounds containing O-H, N-H and F-H bonds Water, Bonding between Nitogen Bases pairs in DNA Dipole Dipole bond less strong Molecules with permanent dipoles and diploes are associated with molecules having electronegative atoms like Oxygen, Nitrogen, Sulfur, Flourine acetone, Tetra chloromethane. Hetero cyclicbase pairs in nucleic acids Dipole -Induced Dipole(Debye forces) weak when a molecule with a permanent dipole to another non-polar molecule with no permanent dipole resulting in electrostatic attraction or repulsion of the electrons from the non-polar molecule.Atoms with larger atomic radii are more polarisable due to this forces Inclustering of proteins, bilological membranes Induced dipole -Induced Dipole bond(London dispersion force) weakest occurs due to temporary repulsion of electrons away from the electrons of a neighboring molecule, leading to a partially positive dipole on one molecule and a partially negative dipole on another molecule folding of proteins, bilological membranes formation