Acetylcholine is a neurotransmitter. The enzyme acetylcholinesterase catalyzes t
ID: 517782 • Letter: A
Question
Acetylcholine is a neurotransmitter. The enzyme acetylcholinesterase catalyzes the following reaction:
During the course of the reaction, the enzyme forms a covalent bond to the substrate.
Indicate whether you think the following is true or false:
A) Acetylcholineterase is used up in the reaction
B) Acetylcholineterase provides an alternative and lower activation energy (DeltaG) for the reaction by interacting strongly with the transition state of acetylcholine.
C) Acetylcholineterase reduces the free energy change (DeltaG) for the reaction.
D) The entropy change for this reaction is likely to be positive.
E) If the enzyme binds strongly to the substrate such that it is relatively more stable than the transition state, the reaction will proceed more rapidly than if the substrate were less stable.
F) Along the path from the reactants to products, several stable intermediates may form, including the transition state.
G) Because acetylcholineterase forms a covalent bond with the substrate, it is not a true catalyst.
H) The transition state has a lower standard free energy than both reactants and products.
CH CH Acetylcholine H20 OH Acetic acid HaC HO Choline CH CHExplanation / Answer
During the course of the reaction, the enzyme forms a covalent bond to the substrate.
Indicate whether you think the following is true or false:
A) Acetylcholineterase is used up in the reaction- false:
B) Acetylcholineterase provides an alternative and lower activation energy (DeltaG) for the reaction by interacting strongly with the transition state of acetylcholine.- true
C) Acetylcholineterase reduces the free energy change (DeltaG) for the reaction.- true.
D) The entropy change for this reaction is likely to be positive. true.
E) If the enzyme binds strongly to the substrate such that it is relatively more stable than the transition state, the reaction will proceed more rapidly than if the substrate were less stable. false:
F) Along the path from the reactants to products, several stable intermediates may form, including the transition state. false:
G) Because acetylcholineterase forms a covalent bond with the substrate, it is not a true catalyst. false:
H) The transition state has a lower standard free energy than both reactants and products. false:
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An enzyme that forms a covalent bond with its substrate during the course of a reaction is considered to undergo covalent catalysis
Acetylcholinesterase (HGNC image ACHE), otherwise called AChE or acetylhydrolase, is the essential cholinesterase in the body. It is a protein that catalyzes the breakdown of acetylcholine and of some other choline esters that capacity as neurotransmitters. Throb is found at essentially neuromuscular intersections and in synthetic neurotransmitters of the cholinergic sort, where its movement serves to end synaptic transmission. It has a place with carboxylesterase group of compounds. It is the essential focus of hindrance by organophosphorus mixes, for example, nerve operators and pesticide .Throb is a hydrolase that hydrolyzes choline esters. It has a high reactant action - every particle of AChE corrupts around 25000 atoms of acetylcholine (ACh) every second, moving toward the point of confinement permitted by dispersion of the substrate. The dynamic site of AChE contains 2 subsites - the anionic site and the esteratic subsite. The structure and instrument of activity of AChE have been clarified from the crystal structure of the enzyme.