In E. coli, the elongation factor EF-Tu forms part of an EF-Tu–GTP–tRNA complex
ID: 521195 • Letter: I
Question
In E. coli, the elongation factor EF-Tu forms part of an EF-Tu–GTP–tRNA complex and increases the rate of tRNA–mRNA binding. GTP hydrolysis to GDP and Pi also enables a type of kinetic proofreading, which prevents the addition of an incorrect amino acid to the growing peptide chain. Determine which of the following statements are true. Check all the true statements.
Question 30 of 33 Incorrect Map a Sapling Learning In E. coli, the elongation factor EF-Tu forms part of an EF-Tu-GTP-tRNA complex and increases the rate of tRNA-mRNA binding. GTP hydrolysis to GDP and Pi also enables a type of kinetic proofreading, which prevents the addition of an incorrect amino acid to the growing peptide chain. Determine which of the following statements are true. Check all the true statements A mismatch between the codon and anticodon does not cause conformational changes, and the Ef-Tu-GTP-aminoacyl-tRNA complex leaves the ribosome before a peptide bond can form. A mismatch between the codon and anticodon creates a distortion in the mRNA-tRNA complex. GDP- Ef-Tu must leave the ribosome before aminoacyl-tRNA can bind to the P site. A correct match between the codon and anticodon causes a conformational change in the small ribosomal subunit and leads to GTP hydrolysis. If the mRNA codon and tRNA anticodon match, EF-Tu-GDP leaves the ribosome. Hydrolysis of GTP associated with EF-Tu brings about a conformational change in the amino acid. One of the statements you chose is incorrect. Recall that the A site binds the aminoacyl-tRNA, the P site binds the peptidyl-tRNA, and the E site binds a deacylated tRNA. Previous 3 Give Up & View Solution Try Again Next ExitExplanation / Answer
4. A correct match between the codon and anticodon causes a conformational change in the small ribosomal subunit and leads to GTP hydrolysis.
3. GDP-EF-Tu must leave the ribosome before aminoacyl-tRNA can bind to the P site
1. GDP-EF-Tu must leave the ribosome before aminoacyl-tRNA can bind to the P site. A mismatch between the codon and anticodon does not cause conformational changes, and the Ef-Tu-GTP-aminoacyl-tRNA complex leaves the ribosome before a peptide bond can form.