Please help me to solve the following case: CASE IN POINT 17.2: A hospital pharm
ID: 548300 • Letter: P
Question
Please help me to solve the following case:
CASE IN POINT 17.2: A hospital pharmacist received the following order for a patient: Medication Order: Staphcillin, 750 mg IV every 4 hours The following product and procedures were followed: Product: 6-g vial Staphcillin Pharmacy Operations: Reconstitute vial with sterile water for injection to yield Staphcillin 500 mg/mL and further dilute in 100 mL of sodium chloride injection. Administer: 30-minute IV infusion (a) How many milliliters of solution from the reconstituted vial should be used per infusion? (b) What should be the infusion rate in milliliters per hour? (c) With a drop factor of 10 drops per milliliter, calculate the infusion rate in drops per minute.Explanation / Answer
a). Reconstituted vial has 500mg/ml staphcillin.
we need 750mg per infusion according to the medication order.
Hence, we need 750mg/500mg/ml=> 1.5 ml of the reconstituted solution per infusion.
b). We further dilute 1.5 ml reconstituted solution in 100ml of sodium chloride solution.
so, dilute injection volume=> 100+1.5=> 101.5 ml
This has to be administered in a 30 minute IV infusion.
Hence, infusion rate=> 101.5 ml/0.5hour=> 203 ml/hour
c) drop factor=> 10 drops per ml
Then, infusion rate in drops per minute=> (203 ml/hour * 10 drops/ml )/60 minutes/hour=> 33.8 ~ 34 drops per minute