Map Sapling Learning Classify the following specific inhibitors or inhibitor cha
ID: 560074 • Letter: M
Question
Map Sapling Learning Classify the following specific inhibitors or inhibitor characteristics according to one of three types of inhibitión: reversible competitive, reversible noncompetitive, or irreversible Note: If you answer any part of this question incorrectly, a single red X will appear indicating that one or more of the phrases are sorted incorrectly Reversible competitive Reversible noncompetitive Irreversible inhibitor binds noncovalently inhibitor does not alter at site other than active site the maximum reaction rate inhibitor binds covalentlyinhibitor structure resembles and permanently at active sitesubstrate structure Hint Check: Answer Next ExitExplanation / Answer
Reversible Competitive Inhibitor (Inhibitor binds reversible to same site as that of substrate binds)
- Inhibitor structure resembles substrate structure
- Inhibitor does not alter the maximum reaction rate (inhibitor does not alter maximum reaction rate and inhibitor structure resembles substrate structure. Eg. Malonate inhibits succinate dehydrogenase)
Reversible Non-Competitive Inhibitor (Inhibitor binds noncovalently at other than active site which leads to conformation change of enzyme. Vmax is lower in the presence of the inhibitor)
- Inhibitor binds nonconvalently at site other than active site
Irreversible Inhibitor (Binds very tightly, usually covalently, to an enzyme. May be at active site or somewhere other than the active site. Eg. Mercury poisoning an enzyme)
- Inhibitor binds covalently and permanently at active site.