Consider the hypothetical serine protease below, which shows the specificity poc

Question

Consider the hypothetical serine protease below, which shows the specificity pockets. The S1 pocket has a glutamic acid in the bottom, the S2 pocket is small and hydrophobic, and the S1' pocket is deep and hydrophobic. Suggest a 3 amino acid sequence that this protease would cleave and indicate between which sites the peptide bond would be broken.

Map S1' Which of the following sequences would this protease cleave? O Met-Arg- Gly O Arg-Met-Gly O Arg- Gly-Met O Met-Gly-Arg O Gly-Met-Arg O Gly-Arg-Met continued below. The peptide bond that is broken is between | and Sl O S2 and S Sp and S1, and S1 and S1'

Explanation / Answer

Following sequence would this protease cleave-

=Gly–Arg- Met

The peptide bond is broken between
= S1 and S1'

Explanation-

Therefore the amino acid side chain must be small and hydrophobic.

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