Map sapling learning Read the text below and answer the question using only your
ID: 59325 • Letter: M
Question
Map sapling learning Read the text below and answer the question using only your knowledge of glycogen metabolism enzymes. A young patient exhibits hypotonia (low muscle tone) and muscle weakness, developmental delays, and failure to thrive. Other findings include cardiomegaly (enlarged heart), hepatomegaly (enlarged liver), and accumulation of a very high concentration of normal lysosomal glycogen in various tissues, including the heart, liver, muscle, and skin. Blood glucose concentration is normal. The disease progresses rapidly. The patient has a glycogen storage disease. Which enzyme of glycogen metabolism is affected? O a-1,4-glucosidase (a hydrolytic enzyme) O amylo o 1,6-glucosidase (debranching enzyme) O branching enzyme O phosphofructokinaseExplanation / Answer
Answer: The enzyme of glycogen metabilism that is affected is alpha 1, 4-glucosidase.
The onset of medical systems provided (like hypotonea, muscle weakness, developmental delays, faiure to thrive, cardiomegaly, hepatomegaly, and mainly lysosomal glycogen are the systems for deficiency of alpha 1, 4-glucosidase. Here, most of the parts of the body get damagaed due to accumulation of glycogen in the lysosome, which is triggered due to the deficiency of the lysosomal acid alpha-glucosidase enzyme.