To fight a multi-drug resistant bacterium you develop a synthetic gene that is s
ID: 62639 • Letter: T
Question
To fight a multi-drug resistant bacterium you develop a synthetic gene that is specifically incorporated into the bacterial genome. It codes for an altered tRNA molecule that, after being transcribed and folded, is always charged with the wrong amino acid. Explain how this experimental treatment affects proteins in the bacterium and explain how the bacterium may be affected by these changes. Underline the following words/terms in your answer: anticodon, ribosome, mutation, and polypeptide chain. Make sure that your answer is complete and cohesive, and that your line of thought is clearly explained. Include 1 figure as illustration.
Explanation / Answer
since bacteria shows MDR behaviour, it means it produces varieties of protein that nulifies the effect of drug and hence bacteria shows resistant to various drug.
if we are introducing the gene mutation in specific t- RNA gene so that it shows alteration during their charging with amino acid and choose wrong amino acid. if it happen such altered tRNA have bind with an amino acid from which its anticodon does not match. so such tRNA does not incorporate those amino acid in polypeptide elongation. and so that due to incorrect amino acid incorporation in protein its become non- functional. such alteration also incorporated in protein those MDR protein. subsequentaly bacteria become prone to drug.