In the stress response you are experiencing while reading this question, epineph
ID: 63280 • Letter: I
Question
In the stress response you are experiencing while reading this question, epinephrine (adrenalin) released from your adrenal glands is stimulating your liver and muscle cells to break down stored glycogen to provide glucose as a source of energy, at least some of which hopefully makes it to your brain. Indicate the correct order of the following events in the epinephrine-stimulated signaling pathway:
A) Activation of adenylate cyclase to produce cAMP
B) Activation of Gs protein by replacement of GDP with GTP and dissociation of the subunits
C) Activation of an enzyme cascade that causes glycogen breakdown and inhibits glycogen synthesis
D) Activation of cAMP-dependent protein kinase
E) Binding of hormone to -adrenergic receptor
Explanation / Answer
The correct order of the following events in the epinephrine-stimulated signaling pathway:
Binding of hormone to -adrenergic receptor
Activation of Gs protein by replacement of GDP with GTP and dissociation of the subunits
Activation of adenylate cyclase to produce cAMP
Activation of cAMP-dependent protein kinase
Activation of an enzyme cascade that causes glycogen breakdown and inhibits glycogen synthesis.
The hormone from the blood stream binds to adrenergic receptor which activates GSalpha protein by replacement of GDP with GTP which leads to dissociation of the subunits which activates adenylate cyclase to produce cAMP which inturn activates cAMP- dependent protein kinase wich activates enzyme cascade that causes glycogen breakdown and inhibits glycogen synthesis.