Match the terms with their appropriate definitions. 1. The pattern of histone mo

Question

Match the terms with their appropriate definitions. 1. The pattern of histone modification acts much like a language or code in specifying alterations in chromatin structure. 2. Enzymes which acetylate the positively charged lysines within the core histone proteins. Histone acetyltransferases 3. Enzyme which attaches a methyl group to the number 5 position of the cytosine base, forming 5-methylcytosine. 4. Proteins which bind methylated sequences. (Click to select) 5 The methylation of DNA that was previously unmethylated (Click to select) __________ 6. Hemimethylated DNA is recognized by DNA methyltransferase, which makes it fully methylated. (Click to select) Terms are: -listone acetyltransferases -listone code hypothesis Methyl-CpG-binding proteins Maintenance methylation De novo methylation DNA methyltransferase

Explanation / Answer

1. Histone code hypothesis

2. Histone acetyltransferase

3. DNA methyltransferase

4. Methyl CpG binding proteins

5. De novo methylation ( this occurs at the early embryo stage and the methylation pattern achieved due to de novo methylation is preserved throughout - they set the pattern of methylation.)

6. Maintenance methylation (methylation of the daughter strand of DNA just after replication- to convert hemimethylated DNA to fully methylated dsDNA)

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