What would be the result of a mutation in Hsp90? Glucocorticoid receptor could n
ID: 64019 • Letter: W
Question
What would be the result of a mutation in Hsp90?
Glucocorticoid receptor could not form a dimmer
The nuclear localization signal would no longer function
Expression of the regulated genes would become constitutive
The hormone would not be able to bind to the glucocorticoid receptor
a)Glucocorticoid receptor could not form a dimmer
b)The nuclear localization signal would no longer function
c)Expression of the regulated genes would become constitutive
d)The hormone would not be able to bind to the glucocorticoid receptor
Explanation / Answer
c. Expression of the regulated genes would become constitutive.
Hsp90 (heat shock proteins 90) is actively invovled in the regulation of cell cycle. Mutation in heat shock protein allows the constitutive expression of regulated genes, which leads to the generation of cancer cells.