Study the nucleotide sequences of wild type and its mutant gene below Wild type:

Question

Study the nucleotide sequences of wild type and its mutant gene below Wild type: Protein: Met-Pro-Glu-Pro-Lys-Mct DNA: ATG CCC AAA CCC AAA ATG Mutant: Protein. Met-Pro-Glu-Pro-Lys-Mct DNA. ATG CCC AAA CCC AAA ATG This mutation can best be called: Non-sense Silent Frameshift Mis-sense All of the above Study the nucleotide sequences of wild type its mutant gene below. Wild type: Protein: Met-Pro-Glu-Pro-Lys-Met DNA: ATCi CCC GAA CCC AAA ATG Mutant: Protein: Met-Pro-Glu-Pro-Lys-Met DNA: ATG CCT GAA CCC AAA ATG This mutation can best be called: Non-sense Silent Frameshift Mis-sense All of the above Study the nucleotide sequences of wild type its mutant gene below. Wild type: Protein: Met-Pro-Glu-Pro-Lys-Met DNA: ATG CCC GAA CCC AAA ATG Mutant: Protein: Met-Pro-Gly-Thr-Glu-Lys DNA: ATG CCC GGA ACC CAA AAT T he mutation can best be called: Non-sense Silent Frameshift Mis-scnse All of the above

Explanation / Answer

29. Option D is correct. Look at both sequences carefully, both are same right. Actually, this is a missense mutation (a point mutation), but there is a mistake in wild-type sequence at 'Glu' (instead of GAA, it is shown as AAA that codes for lysine, please change it in wild-type as GAA (lysine)).

30. Option B is correct answer because both CCC and CCT/U are code for proline itself. There will be no change in the protein sequence in the case of a silent mutation (also a point mutation) hat you have seen in your sequence.

31. This question is highly confusing to answer, It seems like both missense (Option D) and a frameshift mutation (Option C). Glu (GAA) ------> Gly (GGA) and Pro (CCC) -------> Thr (ACC) are looking like a clear missense mutations. But, further aminoacids are not appropriate for the codons (CAA codes Glutamine instead of Glutamate but your wild -type has AAA (lysine), then it is called missense mutation and AAT codes Aspargine ratherthan Lysine but your wild-type has ATG (Met) then it is also called as missense mutation. We cannot say it is frameshift mutation unless deletions or insertions into the DNA sequence. (Anyhow please check it once).

My concluding answer is Mis-sense only (Option D)

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