Can someone answer ASAP please? Figure 4 | TERRA-bound RBPs modify telomere leng
ID: 69060 • Letter: C
Question
Can someone answer ASAP please? Figure 4 | TERRA-bound RBPs modify telomere length Telomere length distribution in interphase nuclei from the indicated siRNA-knockdown primary MEFs. MEFs were obtained from wild-type and Telomerase mutants (Terc)-null embryos . The siRNAs used were: control (C), hnRNP A1 (A1), HuR (H), hnRNP F (F), hnRNP M (M). hnRNP A2B1 (A2B1) and hnRNP D/AUF1 (D/AUF1). Explain the effect of each of these RBPs on telomere length based on the graphs in Figure Does the presence of a functional telomerase (Terc) influence average length of telomeres controlled by each RBP? ExplainExplanation / Answer
Two recent studies on long-lived seabirds demonstrate that the role of telomeres is far from being understood . In 2003, scientists observed that the telomeres of Leach's storm-petrel (Oceanodroma leucorhoa) seem to lengthen with chronological age, the first observed instance of such behaviour of telomeres.[34] In 2006, Juola et al.[35] reported that in another unrelated, long-lived seabird species, the great frigatebird (Fregata minor), telomere length did decrease until at least c.40 years of age (i.e. probably over the entire lifespan), but the speed of decrease slowed down massively with increasing ages, and that rates of telomere length decrease varied strongly between individual birds. They concluded that in this species (and probably in frigatebirds and their relatives in general), telomere length could not be used to determine a bird's age sufficiently well. Thus, it seems that there is much more variation in the behavior of telomere length than initially believed.
n. Furthermore, Gomes et al. found, in a study of the comparative biology of mammalian telomeres, that telomere length of different mammalian species correlates inversely, rather than directly, with lifespan, and they concluded that the contribution of telomere length to lifespan remains controversial. Harris et al. found little evidence that, in humans, telomere length is a significant biomarker of normal aging with respect to important cognitive and physical abilities. Gilley and Blackburn tested whether cellular senescence in paramecium is caused by telomere shortening, and found that telomeres were not shortened during senescence
O. Each round of genetic replication followed by mitosis or meiosis requires the replication of a complete version of each chromosome. Any accidental changes in chromosome structure will be permanent. These changes will be passed on through future rounds of DNA replication. Therefore any loss of DNA is a serious problem. If the end of a DNA strand is not copied each time the DNA is replicated then the chromosome will shrink continuously as the cell cycle continues. Because errors persist and accumulate over time it is very important to prevent the accumulation of DNA damage and loss.