Indicate whether the following statements are TRUE or FALSE. A. The regulation o
ID: 70935 • Letter: I
Question
Indicate whether the following statements are TRUE or FALSE.
A. The regulation of Cdk/Cyclin complexes depends ONLY on phosphorylation and dephosphorylation.
B. DNA replication is initiated at replication origins.
C. While other proteins come and go during the cell cycle, the proteins of the origin recognition complex (ORC) remain bound throughout most of the cell cycle.
D. After the nuclear envelope breaks down, microtubules gain access to the chromosomes, and a probing microtubule connects with a kinetochore and captures the chromosome.
E. Once formed, kinetochore microtubules depolymerize at their plus ends during anaphase.
F. The six stages of mitosis – prophase, prometaphase, metaphase, anaphase, telophase, and cytokinesis – occur in in strict sequential order.
G. Cytokinesis follows mitosis with no overlap between the two events.
Explanation / Answer
A. The regulation of Cdk/Cyclin complexes depends ONLY on phosphorylation and dephosphorylation. -------> FALSE (The regulation of Cdk/Cyclin complexes depends on phosphorylation and dephosphorylation and also by the binding of Cdk inhibitor proteins).
B. DNA replication is initiated at replication origins. ----------> TRUE (Replication of DNA is initiated at replication origins, bacteria contains single origin of replication, while eukaryotes contain multiple origins of replication).
C. While other proteins come and go during the cell cycle, the proteins of the origin recognition complex (ORC) remain bound throughout most of the cell cycle. ------------> TRUE (ORC remain bound to the chromatin throughout most of the cell cycle).
D. After the nuclear envelope breaks down, microtubules gain access to the chromosomes, and a probing microtubule connects with a kinetochore and captures the chromosome. ----------> TRUE
E. Once formed, kinetochore microtubules depolymerize at their plus ends during anaphase ----------> TRUE
F. The six stages of mitosis – prophase, prometaphase, metaphase, anaphase, telophase, and cytokinesis – occur in in strict sequential order ---------> FALSE (Only the first five stages occurs in sequential order, cytokinesis begins during anaphase).