In humans, hemophilia A is an X-linked trait. In human populations, the allele f
ID: 71382 • Letter: I
Question
In humans, hemophilia A is an X-linked trait. In human populations, the allele frequency of the hemophilia A allele is approximately 1 in 10,000. A) What are the allele frequencies for the mutant and normal allele in the human population? B) Among males, what is the frequency of affected individuals? C) Among females, what is the frequency of affected individuals and heterozygous carriers? D) Within a population of 100,000 people, what is the expected number of affected males? In this same population, what is the expected number of carrier females? Assume the population is composed of 50% males and 50% females.
Explanation / Answer
% males and 50% females.
Allele frequency of normal =q=1-p
=1-0.0001
=9.99 X 10-1
Therefore, It is given in the problem that the men and women are equal in the population, So
Among Males the frequency of affected individuals = p= 1X10-4
But the genotypic frequency will be P2+Q2+2PQ=1
Frequency of affected in females = P2 = (1X10-4) =1X10-8
Frequency of heterozygous carrier will be = 2PQ = 2X 1X10-4 X 9.99X10-1
=1.98X10-4