Charles Darwin was plagued by a mysterious chronic disease. It had a variety of
ID: 74943 • Letter: C
Question
Charles Darwin was plagued by a mysterious chronic disease. It had a variety of symptoms including nausea, fatigue, and neurological problems that sometimes incapacitated him for weeks. His voyage on the Beagle is even more remarkable considering the misery of his “seasickness” during the trip.
Based on his symptoms and those of family members, it is thought that Darwin may have suffered from a defect in mitochondrial DNA. What is the likely consequence of such a defect?
When a ligand binds to a G protein-linked receptor, the G protein
Which event may lead to cancer? Select all that apply.
E.Improper replication of DNA during synthesis
A.failure to replicate DNA in reproductive tissues B.elevated ATP production in critical body organs C.reduced ATP production throughout the body D.low pyruvate production due to failure of glycolysis E.vitamin B overdoseExplanation / Answer
First question answer- A- Failure to relicate DNA in reproductive organs
. Mitochondria and mitochondrial disorders are maternally inherited. An examination of Darwin’s family history reveals evidence that Charles Darwin had such an inherited mitochondrial disorder (MELAS syndrome).
Second question- C - G-protein is activated
Many cell-surface receptors are linked to trimeric G proteins. Ligand binding to these receptors, which enclose seven transmembrane domains, result in the activation of an associated signal-transducing G protein.
Third question- A, B, E
DNA replication, Gene mutations, repair and checkpoint activation pathways are extremely regulated and coordinated. Defects or abnormalities in any of these functions result in genomic instability and may further proceed to cancer, premature ageing or disorders associated with severe declivity of genomic integrity.