Please help and explain! The conformations of several nucleosides\' furanose rin
ID: 787605 • Letter: P
Question
Please help and explain!
The conformations of several nucleosides' furanose rings (5-membered rings) were investigated and found to exist in either a "North" envelope (B = nucleic base vertical) or a "South" envelope (-CH2OH vertical). In order to generate more potent anti-HIV activity from these nucleosides, an epoxide FG was added as seen below the equilibrium, (a) What affect does the addition of the epoxide have on the "North-"South" equilibrium? (b) The researchers were aiming to generate more rigid nucleosides, which correlate positively with greater anti-HIV activity. Would you recommend they install an epoxide FG in their nucleosides? Why or why not?Explanation / Answer
The epoxide helps by creating a spot for adition of water or other molecules in epoxide opening, could form a ring structure making it more stable and rigid. yes they should use FG in nucleotides