13) A team of biochemists has been hired by the Olympic Committee of a highly co

Question

13) A team of biochemists has been hired by the Olympic Committee of a highly competitive country to devise a strategy aimed at producing the best long-distance runners and cyclists in the world. Given the strict rules against and sensitive tests for most known performance-enhancing drugs. the clever team decides on a strategy involving genetically engineered Hb. for Which there is currently no test. Their plan is to dope their athletes with a mutant form of lib that is more efficient than wild-type Hb. If you were on this scientific team, would you try to design a new lib with higher or lower affinity for BPG? (hint: consider effects of high elevation adaptation) Given the structure of BPG and Its mode of binding, how might you 90 about this?

Explanation / Answer

Since BPG has a higher binding affinity with deoxygenated Hb than oxygenated Hb, BPG promotes Hb to release more oxygen to the tissue where it requires. Therefore, creating a modified Hb that has more binding affinity to BPG would be beneficial for the athletes, so that BPG binds more to Hb to release more oxygen when it requires.

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