A protein binding site contains a pocket lined with several amino acids that hav
ID: 813305 • Letter: A
Question
A protein binding site contains a pocket lined with several amino acids that have nonpolar side chains. Assuming a good spatial fit, which kinds of functional groups are best suited for placement in this pocket in order to enhance the binding of a ligand?
A protein binding site contains a pocket lined with several amino acids that have nonpolar side chains. Assuming a good spatial fit, which kinds of functional groups are best suited for placement in this pocket in order to enhance the binding of a ligand?
positively charged groups
nonpolar groups.
polar groups.
negatively charged groups.
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Part C
A protein binding site contains a pocket that is dominated by an amino acid with a positively charged side chain. Assuming a good spatial fit, which functional groups in the list below are best suited for placement in this pocket in order to enhance the binding of a drug?
A protein binding site contains a pocket that is dominated by an amino acid with a positively charged side chain. Assuming a good spatial fit, which functional groups in the list below are best suited for placement in this pocket in order to enhance the binding of a drug?
positively charged groups
nonpolar groups.
polar groups.
negatively charged groups.
Explanation / Answer
nonpolar groups.
c) -COO?