Certain aspects of nucleotide synthesis are highly relevant to cancer chemo-ther
ID: 861408 • Letter: C
Question
Certain aspects of nucleotide synthesis are highly relevant to cancer chemo-therapy. Which of the following statements is TRUE?
A. The fact that TMP is needed for DNA synthesis but not for RNA synthesis makes the synthesis of TMP a good target for inhibition of DNA synthesis (for instance in cancer cells).
B. Fluorouracil acts as an anti-cancer drug by irreversibly inhibiting thymidylate synthase (after being converted to fluorodeoxyuridylate)
C. Methotrexate acts as an anti-cancer drug by inhibiting production of tetrahydrofolate, which is needed for synthesis of N5,N10-methylenetratrahydrofolate, which is a cofactor for thymidylate synthase.
D. All of the above are true.
Explanation / Answer
D. All of the above are true.