Question of Map Complete the reaction for the biosynthesis of thymidine monophos

Question

Question of Map Complete the reaction for the biosynthesis of thymidine monophosphate (d TMP) from the substrate and the coenzyme 5 N -methylenetetrahydrofolate (5,10-methylene-THF). Note: Not all terms will be used. 5,10-Methylene-THF d'TMP dihydrofolate dUTP dCMP dUMP tetrahydrofolate Select the three true statements. The enzyme that catalyzes this reaction is a target for the treatment of cancer. 5,10-methylene-THF must be regenerated from DHF in order to continue to produce The sole purpose of 5.10-methylene-THF is to donate hydrogen atoms. O This reaction is catalyzed by thymidylate synthase. This reaction is part of all three salvage synthesis pathways of dTTP

Explanation / Answer

Ans: deoxyuridylate (dUMP) + 5,10-Methylene-THF ----> dTMP + dihydrofolate

In this sysnthesis, deoxyuridylate (dUMP) is methylated to deoxythymidylate (dTMP), The methyl donor in this reaction is 5,10-methylenetetrahydrofolate.

True statments:

1. The enzyme that catalyzes this reaction is a target for treatment of cancer.

2. 5,10-methylene-THF must be regenerated from DHF in order to continue to produce dTMP.

3. This reaction is catalyzed by thymidylate synthase

Related Questions

Navigate

• Browse (All)
• Browse Q
• Subjects

---