Order the initial steps of Merrifield\'s peptide synthesis procedure. Enter the

Question

Order the initial steps of Merrifield's peptide synthesis procedure. Enter the step number (1-6) in the box. Remove protecting group from attached amino acid's a-amino group. Attach Fmoc-protected C-terminal amino acid to resin by its carboxyl group. Add 2^nd amino acid with DCC-activated carboxyl group. alpha-amino group of 1st amino acid attacks the activated carboxyl group of the 2nd amino acid. Repeat the cycle by adding the next amino acid in the peptide sequence (a-amino group is Fmoc- protected; a-carboxyl group is DCC-activated). Wash away the unreacted amino acid.

Explanation / Answer

1) attach Fmoc-protected

2) remove protecting group..

3)add 2nd amino acid with...

4) alpha amino group of 1st amino acid

5) wash away the unreacted amino acid

6) repeat the cycle

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