Stromal cell-derived factor 1 (SDF1) is a secreted protein that plays a major ro
ID: 90099 • Letter: S
Question
Stromal cell-derived factor 1 (SDF1) is a secreted protein that plays a major role in guiding the migration of various cells during development. It binds to a G-protein-coupled receptor on the surface of the migrating cell, which in turn activates a trimeric G protein containing a Gi subunit. Pertussis toxin (PTX) modifies and inactivates the Gi subunit. What would you expect to observe if migrating cells are treated with PTX? A.They migrate toward the source of SDF1. B.They migrate away from the source of SDF1. C.They migrate in a certain direction chosen randomly. D.They move in small steps in random directions. E.They lose their motility. Stromal cell-derived factor 1 (SDF1) is a secreted protein that plays a major role in guiding the migration of various cells during development. It binds to a G-protein-coupled receptor on the surface of the migrating cell, which in turn activates a trimeric G protein containing a Gi subunit. Pertussis toxin (PTX) modifies and inactivates the Gi subunit. What would you expect to observe if migrating cells are treated with PTX? A.They migrate toward the source of SDF1. B.They migrate away from the source of SDF1. C.They migrate in a certain direction chosen randomly. D.They move in small steps in random directions. E.They lose their motility. Stromal cell-derived factor 1 (SDF1) is a secreted protein that plays a major role in guiding the migration of various cells during development. It binds to a G-protein-coupled receptor on the surface of the migrating cell, which in turn activates a trimeric G protein containing a Gi subunit. Pertussis toxin (PTX) modifies and inactivates the Gi subunit. What would you expect to observe if migrating cells are treated with PTX? A.They migrate toward the source of SDF1. B.They migrate away from the source of SDF1. C.They migrate in a certain direction chosen randomly. D.They move in small steps in random directions. E.They lose their motility. Stromal cell-derived factor 1 (SDF1) is a secreted protein that plays a major role in guiding the migration of various cells during development. It binds to a G-protein-coupled receptor on the surface of the migrating cell, which in turn activates a trimeric G protein containing a Gi subunit. Pertussis toxin (PTX) modifies and inactivates the Gi subunit. What would you expect to observe if migrating cells are treated with PTX? A.They migrate toward the source of SDF1. B.They migrate away from the source of SDF1. C.They migrate in a certain direction chosen randomly. D.They move in small steps in random directions. E.They lose their motility.Explanation / Answer
They migrate away from the source of SDF1 is the answer
Explanation:
Per treatment with pertussis toxins inhibit SDF1 and induced LIMkI activation.
Also SDF1 mediated chemotaxis the putative chemorupulsion behavior is sensitive to pertussis toxins (PTX) implicating Go mediated signalling in this process.