Formation of Aspartame Which of the following will result in removal of a benzyl
ID: 907404 • Letter: F
Question
Formation of Aspartame
Which of the following will result in removal of a benzyl ether protecting group?
-Basic hydrolysis and decarbonylation
-Basic hydrolysis
-Decarbonylation
-Catalytic hydrogenolysis
-Basic hydrolysis, decarbonylation, and catalytic hydrogenolysis
Why does the phenylalanine methyl ester not require addition of a protecting group?
-It is not reactive enough
-The phenyl group serves as its own protecting group
None of the answers in this selection are correct
-The methyl ester serves as its own protecting group
-It is too reactive to need a protecting group
Explanation / Answer
Catalytic hydrogenolysis
benzyl deprotection takes place with only hydrogenolasis in the presence of Pd/C
phenylalanine methyl ester
here free -NH2 group is still there with out protection
suppose if you are talking abput acid group then
The methyl ester serves as its own protecting group is correct answer