Place the following events of complement-induced inflammation in the correct chr

Question

Place the following events of complement-induced inflammation in the correct chronological order. Assume all of the complement components are cleaved before recruitment of other immune cells. (l=earliest event, 6=latest event)___1____Numerous C3b bind to bacterial cell membrane ____Killing of bacterium ______C5 convertase cleaves C5 into C5a and C5b ______C3a and C5a act on blood vessels to increase vascular permeability_______Migration of immune cells to site of infection_____C3b binds to C4b2a to form C4b2a3b complex

Explanation / Answer

Answer:

Sequence of events in Complement induced inflammation in correct chronological order:

1) Numerous C3b bind to bacterial cell membrane

2) C3b binds to C4b2a to form C4ba3b complex

3) C5 convertase cleaves C5 into C5a and C5b

4) C3a and C5a act on blood vessels to increase vascular permeability

5) Migration of immune cells to site of infection

6) Killing of bacterium

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