The following TLC of two pure compounds and one reaction mixture was run on a si
ID: 916429 • Letter: T
Question
The following TLC of two pure compounds and one reaction mixture was run on a silica plate in methylene chloride. If column chromatography was run on a mixture of Compounds A and B using silica gel and methylene chloride, which compound would elute first? If the column chromatography was run in hexanes instead of methylene chloride (question # 1), which compound would elute first? Column chromatography (alumina gel) is run on a mixture of ferrocene and acetylferrocene. Both compounds elute at the same time when methylene chloride is the eluting solvent, but only ferrocene elutes when hexanes is the eluting solvent. What can be said about the polarity of ferrocene versus the polarity of acetylferrocene?Explanation / Answer
1. Both the compounds would elute at the same time because of the polar nature of methylene chloride and the fact that like dissolves like. Nonpolar and polar compounds elute at the same time.
2. Compound B would elute first because hexane is a nonpolar solvent.
3. Acetyl ferrocene is more polar than ferrocene. As hexane and ferrocene are nonpolar compounds.