Need help with medchem problem 3?!! x Course: 15 x uno mrooms 3.net/plug X C Che

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Need help with medchem problem 3?!!

x Course: 15 x uno mrooms 3.net/plug X C Chegg Study Guided S x 5FALL-CHEM371 Signature Page c uno mrooms 3.net/pluginfile.php/1076955/mod resource/content/1/CHEM3710H8-F2015.pdf CHEM 3710 Homework 8 (50 pts) Due: 12 noon, December 4, 2015 Problem 3 The compound below was selected as a target for drug development. However the compound is not easily synthesized. Generate a Craig Plot (u, x-axis/om, y-axis) to evaluate the electronic (om) and lipophilic (T) effects of X. Select a training set of four to five compounds to establish an initial SAR. OH F Cl Br OH CO2H NO2 CN CONH2 CF3 NH2 0.0 -0.07 -0.07 -0.10 034 0.37 0.39 0.12 0.37 071 0.56 0.0 0.58 1.01 1.68 0.14 0.71 0.86 -0.67 -0.25 0.37 -0.35 0.98 a 10 37 PM 12/1/2015

Explanation / Answer

Ans: In craig plot, the substituents fall in upper right-hand quadrant area was suitable for future analogs.

For the above compound, the following substituents are suitable

X = -F,-Cl,-Br, -NO2, -CF3

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